|View Larger Image|
Reduced Glutathione Suppositories - 30 Count
A healthy eye contains glutathione in very high concentrations, whereas low levels adversely affect the eye. Glutathione maintains the water balance in the lens. It is synthesized in the lens (and elsewhere) and is essential to normal metabolism. Glutathione can benefit lens function by:
Cataracts: Glutathione as a Protective Bio-Mechanism
Although the oxygen level within the eye lens is very low, the lens still derives a substantial proportion of ATP from mitochrondrial (aerobic) oxidative phosphorylation, which creates free radicals as an unwanted by-product. Glutathione provides the most important protection against damage from free radical and other oxidants. Glutathione is a very small specialized protein (a tripeptide) consisting of three amino acids: glutamic acid, cysteine, and glycine. Glutathione is concentrated within the eye lens and is readily oxidized by damaging oxidants. Those oxidants are chemically reduced (neutralized) as glutathione is chemically oxidized in cytoplasm of cells within the lens. When glutathione levels decline in the epithelial cells (or the entire lens), cell damage and cataract formation can occur unabated.
Lens epithelial cells and superficial lens fiber cells synthesize glutathione. Additional glutathione is transported into the lens from the aqueous humor. Oxidized glutathione can be regenerated (i.e., reduced) by the enzyme glutathione reductase that uses the coenzyme called reduced nicotinamide adenine dinucleotide phosphate (NADPH), which is the cofactor derived from the dietary or supplemental B vitamin: niacin or niacinamide, also known as vitamin B3. Regeneration of reduced glutathione from oxidized glutathione is especially important because it is the chemically reduced form of glutathione that is effective in neutralizing (chemically reducing) free radicals. Glutathione is unique in its ability to regenerate its chemically reduced state by simply finding an electron donor. This cycle allows one molecule of glutathione to continually act as a free radical scavenger.Reduced glutathione diffuses into the lens fiber cells, moving toward the lens center, while oxidized glutathione moves toward the lens surface. Impediment of diffusion in an older lens is a possible cause of nuclear cataract. The rate of diffusion between superficial and deeper layers of the lens decreases with age. Consequently, proteins and lipids in nuclei of older lens are more affected by oxidative stress.
The Best Way to Get Reduced Glutathione to Your Eye
Oral administration of glutathione doesn't work as the digestive system breaks glutathione down into its amino acid building blocks. The Zetpil Glutathione suppository overcomes this problem. Glutathione is considered to be the most powerful, most versatile, and most important of the body's self-generated antioxidants. Used by many alternative doctors for Cataracts, plus all of the diseases listed below, the Zetpil Glutathione Suppository is now available outside the doctor’s office. Low levels of Glutathione are found in almost every person with cataracts.
Although many have touted the benefits of this product, it was sold for many years as an oral supplement. However, it is well known that ORAL SUPPLEMENTATION OF ALL FORMS OF GLUTATHIONE DOES NOT RAISE TISSUE LEVELS OF GLUTATHIONE. Therefore the only way one could truly raise the reduced glutathione levels in body was by undergoing costly direct intravenous administration of reduced glutathione.
What makes this product truly revolutionary is that clinical case studies have demonstrated we are now able to raise tissue levels of reduced glutathione by our ability to combine pure pharmaceutical grade Reduced Glutathione into our proprietary patent pending suppository base, thus effectively allowing Reduced Glutathione in combination with N Acetyl Cysteine to be delivered directly into the blood stream effecting an elevation of the serum glutathione levels.
For an alternative to the Reduced Glutathione Suppository you may be interested in Reduced Glutathione Spray with Therasomal, liposomal, Phospholipid Nanosphere Delivery, 1.7 oz, from Quicksilver Scientific.
If I have cataracts or other eye ailments, why to I care about Glutathione?
The reducing compound glutathione (GSH) exists in an unusually high concentration in the eye lens where it functions as an essential antioxidant vital for maintenance of the tissue's transparency - and a protection against cataracts. In conjunction with an active glutathione redox cycle located in the lens epithelium and superficial cortex, GSH detoxifies potentially damaging oxidants such as H2O2 and dehydroascorbic acid.
Recent studies have indicated an important hydroxyl radical-scavenging function for GSH in lens epithelial cells, independent of the cells' ability to detoxify H2O2. Depletion of GSH or inhibition of the redox cycle allows low levels of oxidant to damage lens epithelial targets such as Na/K-ATPase, certain cytoskeletal proteins and proteins associated with normal membrane permeability. The level of GSH in the nucleus of the lens is relatively low, particularly in the aging lens, and exactly how the compound travels from the epithelium to the central region of the organ is not known.
Recently, a cortical/nuclear barrier to GSH migration in older human lenses was demonstrated by Sweeney et al. The relatively low ratio of GSH to protein -SH in the nucleus of the lens, combined with low activity of the glutathione redox cycle in this region, makes the nucleus especially vulnerable to oxidative stress, as has been demonstrated with use of in vivo experimental animal models such as hyperbaric oxygen, UVA light and the glutathione peroxidase knockout mouse. Effects observed in these models, which are currently being utilized to investigate the mechanism of formation of human senile nuclear cataract, include an increase in lens nuclear disulfide, damage to nuclear membranes and an increase in nuclear light scattering. A need exists for development of therapeutic agents to slow age-related loss of antioxidant activity in the nucleus of the human lens to delay the onset of cataracts.
In another recent study conducted in Germany, glutathione levels were measured in normal human lenses (obtained from an eye bank) and from cataract lenses obtained from routine cataract surgery. In normal lenses, glutathione levels decreased gradually with advancing age. Cataract lenses contained only about one-tenth as much glutathione as normal lenses. As glutathione levels fell, oxidation of lens proteins increased. There is evidence that oxidation of lens proteins is a significant factor in the development of cataracts. Glutathione is one of the major antioxidants (which provide protection against oxidation) found in our lens tissue. The development of cataracts is often preceded by a decline in lens glutathione levels. Strategies designed to prevent glutathione depletion may therefore help prevent cataracts.
Zetpil-RX Reduced Glytathione Suppository
Ingredients and Suggested Use
Dosage: 1 suppository
Dosages per Package: 30
Each Reduced Glutathione & Orotates suppository contains the following: Reduced Glutathione 225 mg, Proprietary blend of NAC, Taurine and reduced Glutathione 12X. Suppository Base:
The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives.
This product contains an extract from soybeans. This product contains no milk, egg, fish, peanuts, crustaceans (lobster, crab, shrimp),
tree nuts, wheat, yeast, gluten, corn, rice sugar, artificial sweeteners, flavors, colors or preservatives.
It is RECOMMENDED that you always attempt to move your bowels prior to inserting the suppository to avoid discharging of the suppository before the suppository can be totally absorbed. It is recommended that the suppository be retained for at least 30 (thirty) minutes to insure adequate absorption of the nutrients, neutraceutical and herbal ingredients contained herein.
In rare case, minor side effects may cause rectal pressure and urge to defecate. If you experience any such effects, refer to Frequently Asked Questions or How to Take a Rectal Suppository insert to adjust dosage accordingly.
In rare case, minor side effects may cause rectal pressure and urge to defecate. If you experience any such effects, adjust dosage accordingly.
This suppository contains Vitamin C. However, when taking N-acetyl –cysteine it is recommended that two to three times as much vitamin C be taken. Vitamin C is depleted because of the prolonged presence off the oxidized cysteine
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.
Among glutathione's many important properties are:
Therapeutically, Glutathione is:
- Glutathione: a vital lens antioxidant
- Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors
- Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes
- Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice
- Specialized protective role of mucosal glutathione in pigmented rabbit conjunctiva
Without ATP the cell becomes sluggish. In some respects ATP is like oil or lubrication is to an engine. Disturbances of the oxidative state cause toxic effects to the DNA.
Oxidative stress contributes to many different health issues, Alzheimer's, Parkinson's disease, atherosclerosis, heart failure, heart attack, and so on according to Wikipedia.