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BioTears 120 ct, relieves dry eye, BioSyntrx
SKU: BIOT7
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Overview

BioTears

BioTears systemically address the root inflammatory cause and effects of dry eyes. It's suggested in peer-reviewed literature that these specific nutrients support normal production of lubricants in other affected parts of the body, such as mucous membranes of the mouth and vagina, and interior body surfaces such as joints and synovial membranes. An intact tear film is necessary for optimal visual acuity.

BioTears Oral GelCaps contain the optimal blend of Omega 3 and Omega 6 essentials fatty acids, plus all the nutrient co-factors suggested in peer-reviewed clinical studies to enhance the metabolic conversion associated with the tear-specific series one anti-inflammatory prostaglandin, PGE1.

BioTears Oral GelCaps include nutrients that are suggested in peer-reviewed clinical studies to appropriately inhibit the essential fatty acid arachidonic acid production of the COX2 enzyme, the pro-inflammatory prostaglandin PGE2, and Interleukin Il-6.

BioTears Oral GelCaps include nutrients that are suggested to modulate goblet cell/mucin production in both the stimulated and unstimulated tear, the lacrimal gland aqueous output, as well as the meibomian gland oil output, which is vital to the prevention of evaporative dry eyes. BioTears also contain APO-Lactoferrin, which is suggested to inhibit the growth of both viral and bacterial pathogens and biofilms in the three-layer tear film.

Supplement Facts

Suggested Use: Four oral capsules per-day; two with each morning and evening meal.

Serving Size: 2 gel caps

Servings Per Container: 60

Amount Per Serving

Calories

Calories from Fat

10

10

Fat

1 g

Vitamin A (preformed retinol from cod liver oil)

1000 IU

Vitamin C (as ascorbic acid)

100 mg

Vitamin D (from cod liver oil)

84 IU

Vitamin E (mixed tocopherols)

32 IU

Vitamin B6 (as pyridoxine hydrochloride)

10 mg

Magnesium (as magnesium sulfate)

20 mg

Black Currant Seed Oil (GLA-120 mg)

798 mg

Cod Liver Oil (EPA 29 mg, DHA 21 mg)

210 mg

Aloe Vera Oil (source of mucopolysaccharides)

262 mg

Turmeric (Curcuma longa – root extract 95% curcuminoids)

50 mg

Green Tea leaf extract (50% EGCG)

50 mg

Lactoferrin (derived from milk compounds)

10 mg

Other Ingredients: Gelatin, glycerin, soy lecithin, carob extract, yellow beeswax, titanium dioxide and water.


BioTears Scientific Rationale

 

Artificial tears flush out debris, dilute substances trapped in the tear film, and increase tear clearance. They do not, however, provide all the factors critical for the maintenance and repair of the ocular surface, nor do they optomize tear film structure and function, which is necessary for improved visual acuity.

  • Clinically suggested to improve the tear chemistry and the health of the ocular surface on over 75% of the dry eye patients studied.
  • Clinically suggested, through slit lamp observation, rose bengal staining, and lisemine green staining to improve the health of the ocular surface.
  • Clinically suggested to extend tear break-up time (TBUT).
  • Clinically suggested to increase aqueous output through the use of both ZoneQucik and Schrimers tests.
  • Clinically suggested to increase tear lactoferrin levels with the Touch Tear MicroAssay System.
  • BioTears has been clinically suggested to decrease tear film inflammatory markers, IL-1 and IL-6.
     

The scientists at Biosyntrx have discovered a unique way to address many of the underlying inflammatory processes associated with dry eye syndrome. Oral administration of specific omega 6 essential fatty acids that contain sufficient amounts of gamma-linolenic-acid (GLA) are suggested to stimulate the natural production of tear-specific anti-inflammatory series one prostaglandins (PGE1). We use Black Currant Seed Oil as our source of omega 6 GLA because it is more stable than either Borage Oil or Evening Primrose Oil. We do not use Flax Seed Oil because it is the most unstable of the essential fatty acid oils, and it does not contain GLA. Flax stability issues keep it from easily converting to GLA, which it must do to produce tear-specific anti-inflammatory PGE1.(1-3)

Clinical studies have suggested that the nutrient co-factors included in BioTears Oral Gel Caps may restore normal production of lubricants in the eyes and other affected parts of the body, such as mucous membranes of the mouth and vagina, and interior body surfaces such as joints and synovial membranes. (4)

In developing a tear-specific formula for oral administration, Biosyntrx included the nutrient co-factors suggested necessary to address dry eye syndrome by physiologic rather than pharmacological means. These ingredients are designed to work synergistically rather than individually, and are suggested in published scientific literature to effectively address the inflammatory process responsible for most dry eye syndrome, as well as enhancing and restoring function to the glands involved in all three layers of the tear film. (5-11)

Mechanism of Action:

Omega 6 fatty acids are suggested to metabolize to the site-specific anti-inflammatory ecosinoid, prostaglandin E1 (PGE1). These particular prostaglandins are suggested in peer-reviewed published literature to reduce ocular surface inflammation, as well as reduce the inflammatory process associated with meibomitis and reduced lacrimal gland aqueous output.

Omega 6 fatty acids convert to PGE1 via the linoleic-acid (LA) to gamma-linolenic-acid (GLA) to dihomo-gamma-linolenic-acid (DGLA) to the series one prostaglandins (PGE1). To help ensure this conversion, we included the nutrient co-factors, vitamins A, C, B6, and magnesium. The delta-six-desaturase (D6D) enzyme necessary for this conversion is too easily disrupted by alcohol, aging, smoking, elevated cholesterol levels, and environmental factors without these additional nutrient co-factors, which are also suggested to modulate goblet cell production and neurotransmitter blink response.

biotears metabolic chart

Pharmaceutical grade cod liver oil, as a source of Omega 3 EPA/DHA is germane to the formulation. It serves as a metabolic gateway boost to the downstream conversion of the Omega 3 to the anti-inflammatory PGE3, while also preventing inappropriate Omega 6 arachidonic acid cleavage via the delta-5-destaurase enzyme (D5D). (12-13)

Vitamin E, specifically gamma tocopherols, is suggested in peer-reviewed literature to prevent oxidation by stabilizing the EFAs, and inhibiting COX2 enzyme activity that promotes inflammatory response. (14)

Curcumin is suggested in peer-reviewed literature to appropriately block Omega 6 and Omega 3 fatty acids from metabolizing to the pro-inflammatory PGE2 and IL1. (15)

Background: Curcumin is a natural COX2 inhibitor with similar chemical properties to ibuprofens Motrin and Advil (NSAIDS). The difference is Curcumin does not inhibit production of the COX1 enzyme that is necessary to protect the stomach lining. NASIDS can cause hemorrhage and have been responsible for a number of deaths. The first sign of an adverse response can be severe gastric bleeding.

Vitamin C, as ascorbic acid and fat-soluble absorbyl palmitate, is suggested to best modulate prostaglandin (PGE1) synthesis due to the extended half-life of the fat-soluble vitamin C over water-soluble ascorbic acid. This Vitamin C combination is also suggested in peer-reviewed literature to enhance the production of IgE concentrates in tears, the first line of basophil and mast cell defense against invading pathogens and allergens that frequently cause dry eye symptoms. (16)

Lactoferrin is suggested in peer-reviewed literature to increase the level of iron binding proteins to better inhibit viral and bacterial infections and to balance other tear lipocalins (family of proteins that transport small hydrophobic molecules), which modulate the surface tension of the tear film and affect the comfort of the contact lens wearer. Lactoferrin taken orally appears to survive absorption in the stomach by converting to a very small molecule called lactoferricin which can easily find its way into secretory tissue including the eyes. (17-24)

Background: Lactoferrin is produced in the tear film by neutrophils that constitute the "first line of defense" against infection. Neutrophil apoptosis (programmed cell death) signals the macrophage to clean up debris from wound sites, including surgically induced wounds (LASIK).

BioTears Oral GelCaps are designed to help inhibit the LASIK induced dry eye by supporting post-surgical wound healing response, enhancing lacrimal and meibomian gland output, as well as enhance the post-op acetylcholine neurotransmitter blink response. (25-28)

Warnings:
Precautions: Coumadin patients should consult their primary care physician when taking this formulation. Pregnant or lactating women, or individuals with medical conditions should also consult a physician before using. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, or treat any disease.

References:

    • Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Barabino S, Rolando M, Camicione P, Ravera G, Zanardi S, Giuffrida S, Calabria G. Cornea. 2003 Mar;22(2):97-10 [abstract]
    • Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. Wu D, Meydani M, Leka LS, Nightingale Z, Handelman GJ, Blumberg JB, Meydani SN. American Journal of Clinical Nutr. 1999 Cot;70(4):536-43. [abstract]
    • Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. Johnson MM, Swan DD, Surette ME, Stegner J, Chilton T, Fonteh AN, Chilton FH. J Nutr. 1997 Aug;127(8):1435-44. [abstract]
    • Sjogren's syndrome and the sicca syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and vitamin C. Horrobin DF, Campbell A. Med Hypotheses 1980 Mar;6(3):225-32 [abstract]
    • The immunoregulatory role of vitamins A, D and E in patients with primary Sjogren's syndrome. Szodoray P, Hovath IF, et al. Rheumatology 2009 Nov 27 [abstract]
    • A compositional based model for the tear film layer. McCulley JP, Shine W. Trans Am Ophthalmol Soc. 1997;95:79-88; discussion 88-93. [abstract]
    • Impact of antiandrogen treatment on the fatty acid profile of neutral lipids in human meibomian gland secretions. Sullivan BD, Evans JE, Krenzer KL, Reza Dana M, Sullivan DA J Clin Endocrinol Metab. 2000 Dec;85(12):4866-73. [abstract]
    • Identification by gas chromatography/mass spectrometry of long-chain fatty acids and alcohols from hamster meibomian glands using picolinyl and nicotinate derivatives. Harvey DJ. Biomed Chromatogr. 1989 Nov;3(6):251-4 [abstract]
    • Vitamin E prevents changes in the cornea and conjunctiva due to vitamin A deficiency. Fujikawa A, Gong H, Amemiya T. Graefes Arch Clin Exp Ophthalmol. 2003 Apr;241(4):287-97. [abstract]
    • Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Tei M, Spun-Michaid SJ, et al. Invest Ophthalmol Vis Sci. 2000 Jan;41(1):82-8. [abstract]
    • Lacrimal gland uptake and metabolism of ascorbic acid. Dreyer R, Rose RC. Proc Soc Exp Biol Med. 1993 Feb;202(2):212-6. [abstract]
    • Relationship between goblet cell density and tear function tests. Yeo AC, Carkeet A, Carney LG, Yap MK. Ophthalmic Physiol Opt. 2003 Jan;23(1):87-94. [abstract]
    • Pro- and Anti-inflammatory Forms of Interleukin-1 in the Tear Fluid and Conjunctiva of Patients with Dry-Eye Disease Abraham Solomon, Dilek Dursun, Zuguo Liu, Yuhuan Xie, Angelo Macri and Stephen C. Pflugfelder. Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2283-92. [abstract]
    • Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH. J Nutr. 2000 Aug;130(8):1925-31. [abstract]
    • Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells Jiang Q, Elson-Schwab, Courtemanche C, Ames BN Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11494-9. [abstract]
    • Safety and Anti-Inflammatory Activity of Curcumin: A Component of Turmeric (Curcuma longa). Chainani-Wu N. Altern Complement Med 2003 Feb;9 (1): 161-8 [abstract]
    • Pseudokeratoconus caused by rosacea. Dursun D, Piniella AM, Pflugfelder SC. Cornea 2001 Aug;20(6):668-9 [abstract]
    • Tear lipocalins: potential lipid scavengers for the corneal surface. Glasgow BJ, Marshall G, Gasymov OK, Abduragimov AR, Yusifov TN, Knobler CM Invest Ophthalmol Vis Sci 1999 Dec;40(13):3100-7 [abstract]
    • The inhibition of mast cell activation by neutrophil lactoferrin: uptake by mast cells and interaction with tryptase, chymase and cathepsin G. HeS, McEven AR, blewell SA. Biochem Pharmacol 2003 Mar 15; 65 (6): 1007-15 [abstract]
    • Components responsible for the surface tension of human tears. Nagyova B, Tiffany JM. Curr Eye Res 1999 Jul;19(1):4-11 [abstract]
    • Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NFkappa B. Haversend L, Ohlsson BG, Hahn-Sone M. et al. Cell Immunol. 2002 Dec; 220 (2); 83-95 [abstract]
    • Bovine lactoferrin stimulates the phagocytic activity of human neutrophils: identification of its active domain. Miyacchi H, Hashimoto S, et al. Cell Immunol. 1998 Jul 10;187(1):34-7. [abstract]
    • What is dry eye and what does it mean to the contact lens wearer? Foulks, GN. Eye Contact Lens. 2003 Jan;29(1 Suppl):S96-100; discussion S115-8, S192-4. [abstract]
    • A multi-centre study of lapsed contact lens wearers. Ophthalmic Physiol Opt. 2002 Nov;22(6):516-27. [abstract]
    • Lipid, lipase and lipocalin differences between tolerant and intolerant contact lens wearers. Glassom M, Stapleton F. Willcox M Curr Eye Res. 2002 Oct; 25 (4); 227-35 [abstract]
    • Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. Macri A, Giuffrida S, et al. Graefes Arch Clin Exp Ophthalmol. 2003 May 27 [epub ahead of print] [abstract]
    • Influence of corneal refractive surgery on the lacrymal film. Pisella PJ, Godon C, Auzerie O, Baudouin C. Fr Ophtalmol 2002 Apr;25(4):416-22 [abstract]
    • Diagnosis and therapy of LASIK-induced neurotrophic epitheliopathy. Breil P, Frisch L, Dick HB. Ophthalmologe 2002 Jan;99(1):53-7 [abstract]
    • Dry eye after refractive surgery. Ang RT, Dartt DA, Tsubota K. Curr Opin Ophthalmol 2001 Aug;12(4):318-22 [abstract]



* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases.

 

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