Item Catalog Number: MACULA COMPLETE
180 Capsules
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BioSyntrx Macula Complete is a complete formula of vitamins, minerals and antioxidant phytochemicals designed to support optimal body and retinal function. Age-related cataracts and macular degeneration are the most common cause of vision loss in Americans age 50 and older.

Macula Complete is a high-energy premium broad-spectrum dietary supplement of vitamins, minerals and antioxidant phytochemicals designed to support optimal body and retinal function. When you take Macula Complete you do not need additional multiple vitamin supplements. Macula Complete is Made in the U.S.A in a NSF GMP registered facility.

• Ultimate nutrition for eye health and renewed energy
• Designed to protect the retina and full body from degenerative disease
• Includes the vitamins, minerals and plant-based nutrients in the ARED, LAST and Mitotropic Compound studies, and far more (Omega-3 fatty acids from fish oil are sold separately as EuroMedica EurOmega-3 for optimal product stability)
• Addresses DNA protection, gene signaling, mitochondrial energy production and the inflammatory processes associated with macular degeneration and all retina disease including glaucoma and diabetic retinopathy

Macula Complete includes the nutrients used the three major studies on nutrition as it relates to eye health.

• ARED study
• Lutein Antioxidant Supplement Trial (LAST)
• Phototrop Study (with the exception of Omega-3 fatty acids, which we present as a stand along product, EuroMedica EurOmega-3, to ensure fatty acid stability

The nutrients included in these studies inhibited AMD disease progression in the study participants.

The preformed vitamin A in Macula Complete is retinyl palmitate, which provides adequate vitamin A for night vision, wound healing, immune protection and appropriate cellular differentiation.

Macula Complete is properly balanced with a full-spectrum of minerals, including zinc, copper and manganese, which are all three required to produce manganese super-oxide dismutase (Mn SOD), which is necessary to neutralize singlet oxygen and the super-oxide free-radicals suggested to contribute to vascular disease and degenerative diseases of the eyes, including macula degeneration. This issue is not adequately addressed in products that only include the ingredients in the ARED study formulation. Macula Complete also includes the minerals associated with blood sugar control, chromium and vanadium.

The nutrient levels in Macula Complete do not exceed the Institute of Medicine's (IOM) safe upper limits for long-term daily consumption.

Scientific Rationale Supporting Macula Complete

We are very appreciative of the ARED study and its effect on the eye care professionals understanding of the relationship between nutrients and macular degeneration. However, it is noted in the body of the ARED study that 57% of the study participants were already taking antioxidant vitamins before enrolling in this study, and an additional 13% who were not taking supplements chose to take a multi-vitamin mineral supplement on top of the ARED formulation. Therefore, almost 70% of those in the trial also concurrently took an additional RDA-focused multiple.

The Biosyntrx scientists believes it prudent to offer a potent multiple for the AMD patients that contains generous amounts of full-spectrum supplemental nutrients and antioxidants that addresses the genetic and degenerative aspects associated with all retina disease.

Macula Complete is presented in capsule form to assure bioavailability for the older consumer.

Given the vast amount of science that now supports daily intake of Omega-3 EPA and DHA, we recommend that our concentrated fish oil EuroMedica EurOmega-3 be taken with each daily dose of Macula Complete.

Astaxanthin is an antioxidant that can benefit eye health. It slows the progression of diseases such as cataracts plus reduces eye strain and other more general maladies. A published study show the benefits of daily astaxanthin supplementation. The article in National Eye Care, Inc. reported greater than 50% of the study's participants experienced fewer symptoms of eye fatigue. The participants also showed improvement on visual function tests. In addition to the previous article, the February 2009 issue of "Chemical Research in Toxicology" reports taking astaxanthin supplemnts may reduce the risk of developing cataracts. Cataracts are the clouding of the lens in the eye which can lead to vision loss.¹

Vitamin A at 2,500 IU in Macula Complete as retinyl palmitate, guarantees adequate retinol for night vision, cornea health, wound healing, immune protection and appropriate cellular differentiation. Vitamin A should always be presented with zinc and taurine, since they all three play an important role in optimal photo-receptor function. A number of published studies link excessive amounts of Vitamin A as retinol to hip fracture in older people. Macula Complete Vitamin A does not exceed the Institute of Medicines' current recommendation for daily consumption.

Full-Spectrum Minerals are balanced to provide proper bio-electrical responses at the cellular level. This is a major issue for proper enzymatic function in the human body, including the eye. These minerals include Calcium, Magnesium, Selenium, Boron, Copper, Manganese, Chromium, Vanadium, and Molybdenum.

Carotenoids are a scientifically balanced mixture of beta and alpha carotenoids, 1 mg of lycopene, 16 mg of FloraGlo lutein plus 4 mg of ZeaGold zeaxanthin, which strengthen the macula and has been suggested to lower the risk of developing certain tes of cancers. New science suggests that the central macula has a distinct preference for zeaxanthin. Macula Complete does not included beta carotene. It is considered safe for those who still smoke and those who have ever smoked or been exposed to second-hand smoke.

Bioflavnoids (hesperidin, quercetin, and rutin) strengthen the vascular system, which plays an important role in transporting proper nutrients to every organ in the body including the eye.

Trans-Resveratrol is included at the 100 mg level to enhance mitochondrial function, improve insulin sensitivity, reduce inflammation and protect against toxic effects of high-fat diets. Trans-resveratrol is suggested in a number of studies to mimic caloric restriction benefits linked to protection of chromosome caps, or telomeres, that deteriorate with age. Longer telomeres are associated with both longer lives and healthier aging.

Taurine is included to retard the progressive visual field reduction in retinitis pigmentosa and as the universal carrier of lipid soluble vitamins. Taurine intake is suggested to play a significant role in maintaining fluid balance in the eye.

Carnosine is included to slow the progression of cellular cross-linking associated with cataract formation.

Supplement Facts

*** Patent Pending (#MJ923)

Dosage and Use:

• Take six capsules per day. Take three capsules with each morning and evening meal.

Warnings:

• If pregnant or lactating, consult your physician before taking this product
• Keep out of reach of children
• Do not exceed recommended dose
• Keep container tightly closed in a cool, dry and dark place

References:

1. What Are the Benefits of Taking Astaxanthin?

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.